This question asks us to identify a flaw, so having read the question stem before looking at the argument, we're going to be looking for problems that jump out at us right away - things like circular reasoning, insufficiency of data, a conclusion unsupported in scope by the premises, a faulty assumption. Any of these (and more) are fair game, so it often pays to keep a look out for problems even before you look at the answer choices. Often it helps to pay particular attention to the conclusion in looking for a flaw, since premises - as mere facts - cannot be wrong on their own but only insofar as they result to the larger conclusion.
Let's look at the conclusion before getting to the answer choices: "There is no need to look further for an explanation of the difference in the studies' results" because the studies used different methodologies and got different results (the part not in the quotes is added to give a very short summary of the reasoning of the argument). Well let's think about that before looking at the answer choices.
If you went to 2 different LSAT test prep companies that gave you practice tests, one rating you at a 155 and the other rating you at a 175, would you think that discrepancy didn't need to be explained just because the companies used different tests? Or let's say that you went to two different doctors, where one took an X-ray and the other checked your bones manually - would you be satisfied if they gave you different diagnoses? Of course note! Similarly here, there seems to be a problem with saying that it is reasonable for 2 different methodologies to give opposite answers.
Answer choice (D), the correct answer, gets right at this problem, noting that the author of the argument seems to have ignored the fact that different methods should produce similar or identical results. It matches almost exactly what we should have thought just from examining the conclusion.
Let's look at another answer choice just to see what an incorrect answer choice looks like. (B) says that the author fails to distinguish between the method of an investigation and the purpose of an investigation. But we don't know what the purpose of either of these studies were - to inform government policy? to prove an abstract economic theory? to justify lowering the minimum wage? Who knows? We certainly don't know from the argument.
When identifying a flaw, we are working entirely off what is in the argument. For that reason, it is particularly important to pay attention to scope and degree issues. Quite a number of the wrong answers in this question are out of scope.